Research Assistant Zebrafish High-Throughput Drug Screening for Glaucoma 40%

Department of Immunology, Inselspital, DBMR

The project environment is collaborative and methodologically diverse, aiming for innovation in research.

Key Responsibilities:

• Maintain and prepare zebrafish larvae for high-throughput experimental workflows
• Conduct and analyze visual acuity tests using automated behavioral platforms such as DanioVision
• Prepare, handle, and track drug compound libraries for in vivo screening assays
• Manage molecular and cellular assays, including PCR, qPCR, and Western blot analysis, as needed to validate hits
• Apply statistical and bioinformatics tools (e.g., R, Python) for data analysis and interpretation of behavioral and phenotypic readouts
• Document experimental procedures, contribute to scientific reporting, and support manuscript preparation
• Collaborate effectively within a multicultural, multidisciplinary team and contribute to the supervision and training of junior team members

Desired Profile:

• Ongoing master's degree (or completion) in Molecular Life Sciences, Immunology, Biotechnology, or related field
• Strong background in molecular biology techniques (PCR, qPCR, DNA/RNA extraction, Western blot, flow cytometry)
• Demonstrated skills in gene editing, such as CRISPR/Cas9 or related genome engineering tools
• Hands-on proficiency in laboratory project management and documentation
• Familiarity with animal handling or small vertebrate in vivo models is a plus, but strong willingness to learn is equally valued
• Excellent communication and teamwork skills, with a record of successful interdisciplinary collaboration
• Motivation to apply bioanalytical methods for translational vision research
• As part of our commitment to international scientific exchange, the laboratory is preparing a competitive application for upcoming Swiss Leading House South Asia funding, specifically aiming to establish a collaborative glaucoma research platform with Sri Lankan academic partners. Candidates with a Sri Lankan background are particularly encouraged to apply, as their expertise and cross-cultural fluency will play a pivotal role in shaping and leading this new era of Swiss–Sri Lankan scientific exchange.

We Offer:

• Stimulating scientific environment within a leading Swiss biomedical research institution
• Training in zebrafish vision assays, drug screening, and machine learning techniques for phenotype analysis
• Opportunities for scientific development, including manuscript preparation and conference participation
• Flexible work schedule (40%) suitable for continuing studies

Application:

For any questions regarding the position, please feel free to contact Dr. Federica Maria Conedera directly via E-Mail schreiben. Please send your application including CV, motivation letter, reference letter, University diplomas with grades to E-Mail schreiben until August 15th, 2025.